In this study, 23,084 balls bowled by elite level spin bowlers across six competitions were analysed in order to fulfil two main aims; (1) investigate whether the type of spin bowler presents any tactical advantages and (2) investigate the most effective type of spin bowling variation. The results of logistic regression analyses revealed significant relationships between specific bowler–batter match‐ups and runs conceded (p < 0.001). Specifically, opposing match‐ups where the ball naturally spins away from right‐handed and left‐handed batters were revealed to be a particularly effective strategy at restricting runs conceded. Right-handed leg‐spin bowlers are revealed to be significantly more likely to take the wickets of right‐handed batters. Results also revealed that the ‘googly’ and ‘carrom ball’ variations are particularly effective at both, restricting runs scored and taking wickets when they are bowled to right‐handed batters (both p < 0.001). Evidence suggests that certain bowler–batter match‐ups present some tactical advantages and should therefore be taken into consideration in T20 cricket. Furthermore, the results also highlight the value of a wrist spinner capable of bowling ‘googly’ or ‘carrom ball’ variations. The findings of this study could potentially influence team selection, strategies, recruitment policy and general coaching practice.