Flywheel (FW) resistance training is considered a valid and time-efficient method to improve force production and muscular hypertrophy. However, no definitive consensus exists regarding FW parameters for optimizing chronic training responses. This review therefore aims to examine the FW training literature and provides evidence-based conclusions and practical applications for practitioners. This review reports that FW resistance training is a valid strategy to improve force, power, and hypertrophy responses, however, differences with traditional training programs have not been clearly established and currently it is not possible to state that FW training is superior compared to traditional resistance training methodologies. Moreover, the differences between populations and sex should be studied in further depth to be able to establish robust conclusions. Finally, this review reports variables (duration, volume, and intensity) that should be adopted to improve force, power and hypertrophy responses – even though future research is needed to establish the appropriate training dose for specific populations.