Birak, Kulbir, Terry, Philip and Higgs, Suzanne (2011) Conditioned tolerance to the effects of alcohol on inhibitory controls in humans. Alcohol and Alcoholism, 46 (6). pp. 686-693.

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Abstract

AIMS:
To test whether the repeated consumption of alcohol in a particular environment leads to the emergence of a context-specific conditioned compensatory response (CCR) that can counter alcohol's impairment of inhibitory processes.
METHODS:
Twenty-four participants consumed an alcoholic drink (males: 0.65 g/kg; females: 0.57 g/kg) in one context on three sessions and a matched placebo drink in a different context on three other sessions. At test, participants were split into two groups and consumed a novel alcoholic drink either in the context previously paired with alcohol or the placebo-paired context. On all sessions, participants were tested on two computer-based tasks that measured response inhibition: an affective go/no-go task and a stop-signal task (SST).
RESULTS:
Over the conditioning trials, tolerance developed to alcohol's disinhibitory effects on the go/no-go task; moreover, on the test for conditioned responding, performance was less impaired for participants in the alcohol-paired versus the placebo-paired context. No tolerance was evident on the SST, and no CCR.
CONCLUSION:
Repeated consumption of alcohol in a particular environment can lead to the emergence of a context-specific CCR that counters some of alcohol's disinhibitory effects. Therefore, consuming alcohol in an unfamiliar context might produce stronger disinhibitory effects than would be apparent in a familiar drinking environment.

Item Type:	Article
Uncontrolled Keywords:	Alcohol, Alcoholism
Subjects:	H Social Sciences > H Social Sciences (General) H Social Sciences > HV Social pathology. Social and public welfare
Divisions:	Faculty of Arts, Business & Applied Social Science > Department of Applied Social Sciences
Depositing User:	Kristina Hearnden
Date Deposited:	23 Jul 2015 09:36
Last Modified:	03 Nov 2017 09:19
URI:	https://oars.uos.ac.uk/id/eprint/66

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