Conditioned tolerance to the effects of alcohol on inhibitory controls in humans.

Birak, Kulbir, Terry, Philip and Higgs, Suzanne (2011) Conditioned tolerance to the effects of alcohol on inhibitory controls in humans. Alcohol and Alcoholism, 46 (6). pp. 686-693.

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Abstract

AIMS:
To test whether the repeated consumption of alcohol in a particular environment leads to the emergence of a context-specific conditioned compensatory response (CCR) that can counter alcohol's impairment of inhibitory processes.
METHODS:
Twenty-four participants consumed an alcoholic drink (males: 0.65 g/kg; females: 0.57 g/kg) in one context on three sessions and a matched placebo drink in a different context on three other sessions. At test, participants were split into two groups and consumed a novel alcoholic drink either in the context previously paired with alcohol or the placebo-paired context. On all sessions, participants were tested on two computer-based tasks that measured response inhibition: an affective go/no-go task and a stop-signal task (SST).
RESULTS:
Over the conditioning trials, tolerance developed to alcohol's disinhibitory effects on the go/no-go task; moreover, on the test for conditioned responding, performance was less impaired for participants in the alcohol-paired versus the placebo-paired context. No tolerance was evident on the SST, and no CCR.
CONCLUSION:
Repeated consumption of alcohol in a particular environment can lead to the emergence of a context-specific CCR that counters some of alcohol's disinhibitory effects. Therefore, consuming alcohol in an unfamiliar context might produce stronger disinhibitory effects than would be apparent in a familiar drinking environment.

Item Type: Article
Uncontrolled Keywords: Alcohol, Alcoholism
Subjects: H Social Sciences > H Social Sciences (General)
H Social Sciences > HV Social pathology. Social and public welfare
Divisions: Faculty of Arts, Business & Applied Social Science > Department of Applied Social Sciences
Depositing User: Kristina Hearnden
Date Deposited: 23 Jul 2015 09:36
Last Modified: 03 Nov 2017 09:19
URI: http://oars.uos.ac.uk/id/eprint/66

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