A simple asthma prediction tool for preschool children with wheeze or cough

Pescatore, A M, Dogaru, Cristian, Duembgen, L, Silverman, M, Gaillard, E A, Spycher, B D and Kuehni, Claudia E. (2013) A simple asthma prediction tool for preschool children with wheeze or cough. Journal of Allergy and Clinical Immunology, 133 (1). pp. 111-118. ISSN 0091-6749

A simple asthma prediction tool for pre-school children with wheeze or cough.pdf - Accepted Version

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BACKGROUND: Many preschool children have wheeze or cough, but only some have asthma later. Existing prediction tools are difficult to apply in clinical practice or exhibit methodological weaknesses. OBJECTIVE: We sought to develop a simple and robust tool for predicting asthma at school age in preschool children with wheeze or cough. METHODS: From a population-based cohort in Leicestershire, United Kingdom, we included 1- to 3-year-old subjects seeing a doctor for wheeze or cough and assessed the prevalence of asthma 5 years later. We considered only noninvasive predictors that are easy to assess in primary care: demographic and perinatal data, eczema, upper and lower respiratory tract symptoms, and family history of atopy. We developed a model using logistic regression, avoided overfitting with the least absolute shrinkage and selection operator penalty, and then simplified it to a practical tool. We performed internal validation and assessed its predictive performance using the scaled Brier score and the area under the receiver operating characteristic curve. RESULTS: Of 1226 symptomatic children with follow-up information, 345 (28%) had asthma 5 years later. The tool consists of 10 predictors yielding a total score between 0 and 15: sex, age, wheeze without colds, wheeze frequency, activity disturbance, shortness of breath, exercise-related and aeroallergen-related wheeze/cough, eczema, and parental history of asthma/bronchitis. The scaled Brier scores for the internally validated model and tool were 0.20 and 0.16, and the areas under the receiver operating characteristic curves were 0.76 and 0.74, respectively. CONCLUSION: This tool represents a simple, low-cost, and noninvasive method to predict the risk of later asthma in symptomatic preschool children, which is ready to be tested in other populations.

Item Type: Article
Uncontrolled Keywords: Asthma, wheeze, cough, children, prediction, prognosis, persistence, longitudinal, cohort study
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: Faculty of Arts, Business & Applied Social Science > Department of Young People & Education
Depositing User: Cristian Dogaru
Date Deposited: 11 Dec 2017 14:29
Last Modified: 10 Aug 2020 13:21
URI: https://oars.uos.ac.uk/id/eprint/337

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