The aim was to objectively identify key performance indicators in professional soccer that influence outfield players’ league status using an artificial neural network. Mean technical performance data were collected from 966 outfield players’ (mean SD; age: 25 ± 4 yr, 1.81 ±) 90-minute performances in the English Football League. ProZone’s MatchViewer system and online databases were used to collect data on 347 indicators assessing the total number, accuracy and consistency of passes, tackles, possessions regained, clearances and shots. Players were assigned to one of three categories based on where they went on to complete most of their match time in the following season: group 0 (n = 209 players) went on to play in a lower soccer league, group 1 (n = 637 players) remained in the Football League Championship, and group 2 (n = 120 players) consisted of players who moved up to the English Premier League. The models created correctly predicted between 61.5% and 78.8% of the players’ league status. The model with the highest average test performance was for group 0 v 2 (U21 international caps, international caps, median tackles, percentage of first time passes unsuccessful upper quartile, maximum dribbles and possessions gained minimum) which correctly predicted 78.8% of the players’ league status with a test error of 8.3%. To date, there has not been a published example of an objective method of predicting career trajectory in soccer. This is a significant development as it highlights the potential for machine learning to be used in the scouting and recruitment process in a professional soccer environment.