Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion

Turner, Christopher, Badu-Nkansah, K and Hynes, R.O. (2017) Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. Angiogenesis, 20 (4). pp. 519-531. ISSN 0969-6970

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Abstract

Fibronectin containing alternatively spliced EIIIA and EIIIB domains is largely absent from mature quiescent vessels in adults, but is highly expressed around blood vessels during developmental and pathological angiogenesis. The precise functions of fibronectin and its splice variants during developmental angiogenesis however remain unclear due to the presence of cardiac, somitic, mesodermal and neural defects in existing global fibronectin KO mouse models. Using a rare family of surviving EIIIA EIIIB double KO mice, as well as inducible endothelial-specific fibronectin-deficient mutant mice, we show that vascular development in the neonatal retina is regulated in an autocrine manner by endothelium-derived fibronectin, and requires both EIIIA and EIIIB domains and the RGD-binding α5 and αv integrins for its function. Exogenous sources of fibronectin do not fully substitute for the autocrine function of endothelial fibronectin, demonstrating that fibronectins from different sources contribute differentially to specific aspects of angiogenesis.

Item Type: Article
Uncontrolled Keywords: Fibronectin, neonatal vascular morphogenesis, mutant mice
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Health & Science > Department of Science & Technology
Depositing User: Christopher Turner
Date Deposited: 11 Jul 2017 10:20
Last Modified: 22 Nov 2017 11:55
URI: http://oars.uos.ac.uk/id/eprint/227

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