Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFalpha therapy in rheumatoid arthritis?

Ongaro, Alessia, De Mattei, Monica, Pellati, Agnese, Caruso, Angelo, Ferretti, Stefano, Masieri, Federica, Fotinidi, Maria, Farina, Ilaria, Trotta, Francesco and Padovan, Melissa (2008) Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFalpha therapy in rheumatoid arthritis? Rheumatology international, 28 (9). pp. 901-8. ISSN 0172-8172

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Abstract

In this study we analyzed whether the polymorphisms 676T>G in the tumor necrosis factor receptor (TNFR) II gene and -308G>A in the TNFalpha promoter gene may influence the response grading to anti-TNFalpha therapy in rheumatoid arthritis. We enrolled and genotyped 105 RA patients treated with etanercept (n = 55), infliximab (n = 40) and adalimumab (n = 10) for 1 year. The clinical response was evaluated according to the ACR criteria every 3 months. Patients with TNFRII 676TG genotype was significantly associated with lower ACR response compared with 676TT genotype, at 3 (OR 3.78 95% CI 1.07-13.31) and 12 months (OR 4.30 95% CI 1.16-15.99) of treatment. No significant association between TNFalpha -308G>A polymorphism and the clinical response was found. TNFRII 676TG genotype is associated with a lower response to anti-TNFalpha therapy, independently from the specific agent used. This polymorphism could become a useful genetic marker for predicting the different response grading to anti-TNFalpha therapy.

Item Type: Article
Uncontrolled Keywords: Rheumatoid arthritis, Anti-TNFα therapy, TNFRII 676T<G polymorphism
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Health & Science > Department of Science & Technology
Depositing User: Federica Masieri
Date Deposited: 23 Feb 2021 09:18
Last Modified: 01 Mar 2021 16:08
URI: http://oars.uos.ac.uk/id/eprint/1634

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